After performing the Wilcoxon signed-rank test, we found that the high-risk group was negatively correlated with tumor-infiltrating immune cells, such as neutrophils, M1 macrophages, plasmacytoid dendritic cells, CD4+ T cells, and CD8+ T cells, whereas it was positively correlated with cancer-associated fibroblasts and M2 macrophages. The gene discussed is CD4; the disease is cancer.