Classical pathway analysis showed that the 46 key genes were related to sepsis signal pathway, cellular immune response, HIF-1 signal pathway, erythropoietin triggering signal pathway in endothelial cells, neuroinflammation pathway, wound healing signal pathway, leukocyte overflow signal activation, IL-15 signal pathway, opioid signal pathway, inhibition of neurovascular coupling signal pathway, etc. (Figure 7A; Supplementary Table S3). This evidence concerns the gene HIF1A and Sepsis.