REN and endometrial cancer: Furthermore, the hub module was significantly enriched in the renin-angiotensin system (RAS)-associated genes such as AGT, AVP, and AVPR1A. In a previous study, AVP receptors were predominantly expressed in non-pregnant women (Fuchs et al., 1998), which is consistent with our finding that AVPR1A was upregulated in RIF samples, whereas Pringle et al. found that dysregulation of endometrial RAS could be a predisposing factor to endometrial cancer (Pringle et al., 2016).