Although so far there are no studies about the variations of ISYNA1 in different ethnic groups, the upstream genetic variations may modulate the regulation of ISYNA1. Indeed, the methylation/expression of ISYNA1 is regulated by P53 (Koguchi et al., 2016), and different mutations in P53 gene have been reported in BC among different ethnic groups (Huo et al., 2017). This evidence concerns the gene ISYNA1 and breast cancer.