TP53 and breast cancer: Although so far there are no studies about the variations of ISYNA1 in different ethnic groups, the upstream genetic variations may modulate the regulation of ISYNA1. Indeed, the methylation/expression of ISYNA1 is regulated by P53 (Koguchi et al., 2016), and different mutations in P53 gene have been reported in BC among different ethnic groups (Huo et al., 2017).