Previous studies have shown that the expression of hsa-miR-144-3p in HCC is significantly higher than that in adjacent tissues, and the ratio of HSA144-3p/hsA-miR-21-5p increases significantly during the occurrence of HCC, which is even better than alpha-fetoprotein in ROC curve analysis, suggesting that HSA144-3p may be an excellent predictive marker of liver cancer (Pu et al., 2018). The gene discussed is AFP; the disease is liver cancer.