Current studies about skeletal muscle degeneration/regeneration process focused on mutant SOD1 mouse mode to the pathology of ALS (Cheng et al., 2019; Badu-Mensah et al., 2020; Steyn et al., 2020), but to our knowledge, SCFD1 has never been investigated in molecular biology experiments or genetic models. This evidence concerns the gene SCFD1 and amyotrophic lateral sclerosis.