These included 5q33.1 TNIP1, 9p21.2 C9orf72, 10q25.2 ACSL5, 10q22.2 NDST2, 14q12 SCFD1, 17q12 MYO19, GGNBP2, and ZNHIT3. All these six loci have been previously associated with ALS risk, and all eight genes have been previously suggested as the functional candidates. This evidence concerns the gene ACSL5 and amyotrophic lateral sclerosis.