To examine the expression of these genes in healthy and IL-1b-induced osteoarthritis samples, we performed RT-qPCR and confirmed that IGF2BP3 and YTHDF3 were closely associated with the development of OA and SREBF2, EGR1, and miR-340 could be involved in OA progression by regulating the expression of IGF2BP3 and YTHDF3. However, this study had some limitations. The gene discussed is EGR1; the disease is osteoarthritis.