Furthermore, heat shock proteins (HSPA8 and HSP90B1), annexins (ANXA1, ANXA2, and ANXA5), and vesicle-mediated transport proteins (ACTB, CTTN, STXBP3, MARCO, and YWHAZ), which are essential for normal kidney development, are found to be dysregulated and to contribute to the observed nephrotic syndrome (Smoyer et al., 1996; Markoff and Gerke, 2005; Simsek et al., 2008; Chebotareva et al., 2018). The gene discussed is HSPA8; the disease is nephrotic syndrome.