Bantu, Afro-related ethnolinguistic cultural groups, and Latin America have a similar low proportion of pathogenic variants in most of the sickle cell disease-specific genes, except in MY O 7B, CPS1, COL6A3, MTRR, SLC22A5, ABCC1, and RPL3L (Figure 2D). The gene discussed is SLC22A5; the disease is sickle cell disease.