AKT1 and colorectal carcinoma: Increasing researches have reported that the PI3K/AKT/mTOR molecular signaling pathways play an essential role in the development and progression of CRC which regulate cell survival, growth, proliferation, angiogenesis, invasion, migration and glucose metabolism (Park S. H. et al., 2019; Deng et al., 2019; Jin et al., 2020; Smit et al., 2020).