In SETD7-deficient mice, TGF-β-induced lung fibrosis is highly ameliorated (Elkouris et al., 2016), which indicates SETD7 is a positive regulator in TGF-β signaling, even plays an oncogenic role in TGF-β-mediated cancers, such as breast cancer and glioblastoma (Colak and Ten Dijke, 2017). This evidence concerns the gene TGFB1 and pulmonary fibrosis.