Similarly, SETD7 interacts directly with AR and enhances AR transcriptional activity by methylating its K632 residue (Gaughan et al., 2011), which is not only plays a proliferative role in prostate cancer but is also involved in TNFR and PTEN/PI3K/AKT signaling (Wang et al., 2018). This evidence concerns the gene AR and Familial prostate cancer.