Activated NF-κB, formed by RelA (also called p65) and p50 subunit (Zinatizadeh et al., 2021), translocates into the nucleus and up-regulates target genes after diverse extracellular stimuli, including TNF-α (Hoesel and Schmid, 2013), which might benefit for cell proliferation and survival in leukemia, melanoma, liver, breast, prostate and colorectal cancers (Dolcet et al., 2005). This evidence concerns the gene RELA and melanoma.