Aberrant activation of Hedgehog-GLI axis is reported in human malignancies, including breast, pancreatic, lung and ovarian cancers, which resulted in upregulation of oncogenic genes (Matissek and Elsawa, 2020), such as BCL2, CCND1, MYCN, NANOG, SOX2 and SNAL1. As such, GLI family members might be therapeutic targets in various cancers (Niewiadomski et al., 2019). The gene discussed is GLI1; the disease is cancer.