Activated NF-κB, formed by RelA (also called p65) and p50 subunit (Zinatizadeh et al., 2021), translocates into the nucleus and up-regulates target genes after diverse extracellular stimuli, including TNF-α (Hoesel and Schmid, 2013), which might benefit for cell proliferation and survival in leukemia, melanoma, liver, breast, prostate and colorectal cancers (Dolcet et al., 2005). The gene discussed is NFKB1; the disease is colorectal cancer.