In previous study, GLI3 K436 and K595 residues are methylated by SETD7, which stabilizes GLI3 protein and in turn activates the Sonic Hedgehog pathway, resulting in the expression of downstream genes, including Ptch1. These genes promote proliferation, invasion and metastasis of non-small-cell lung cancer cells (Fu et al., 2016). Here, GLI3 is linked to non-small cell lung carcinoma.