PFKFB3 and neoplasm: Among the top activated pathways, 9/14 (64%) signature genes including JUNB, DUSP1, ID2, KLF6, NFKBIA, NR4A2, PFKFB3, TNFAIP3, and ZFP36, were presented in the TNF α/NF-κB pathway which has been widely reported in tumor cell invasion and metastasis promoting and drug resistance (Wu and Zhou, 2010).