APP and neoplasm: Remarkably, most of the 20 prioritized ligands such as APP, EGF, and IL6, were associated with the process of tumor formation, progression, and invasion as well as confronting the anti-tumor immune response (Figures 2B,C) (Mendelsohn and Baselga, 2000; Lim et al., 2014; Kumari et al., 2016; Shanmugalingam et al., 2016; Liang et al., 2020).