It has been well-documented that JUNB participates in tumorigenesis, progression, and invasion of several tumors like renal cell carcinoma and hepatocellular carcinoma as well as inhibition of the proliferation of adaptive immune cells (Szremska et al., 2003; Guo et al., 2009; Kanno et al., 2012). This evidence concerns the gene JUNB and hereditary clear cell renal cell carcinoma.