Thorsson et al. identified six immune subtypes (C1: wound healing, C2: IFN-γ dominant, C3: inflammatory, C4: lymphocyte depleted, C5: immunologically quiet, and C6: TGF-β dominant) across TCGA pan-cancer and found that distinct subtypes characterized diverse TME (Thorsson et al., 2018). The gene discussed is TGFB1; the disease is cancer.