Therefore, we believe that FMR1 recognizes the upregulation of m6A modification induced by fear stress, thereby triggering degradation of its mRNA and ultimately leading to reduced expression of Mefv. Abnormal changes in Mefv can cause familial Mediterranean fever (FMF) (Grandemange et al., 2011; Kirectepe et al., 2011), and there has been extensive research on Mefv in FMF. Here, MEFV is linked to familial Mediterranean fever.