In addition, pathogenic determinants, such as the material used for device composition, the host extracellular matrix components, such as fibrin and fibronectin, which form a sheath around the catheter, and the extracellular polymeric substance (EPS) produced by the adherent organisms, cause infection, either locally or at a distant site via circulating toxins [9, 10]. This evidence concerns the gene FN1 and infection.