The PLASMIC score system comprises a platelet count of <30,000/μL, evidence of hemolysis (reticulocyte count >2.5%, elevated indirect bilirubin >2 mg/dL, undetectable to low haptoglobin levels), creatinine <2 mg/dL, mean corpuscular volume <90 fL, and international normalized ratio <1.5, with no active cancer or organ/stem cell transplant [13,14]. This evidence concerns the gene HP and cancer.