In this study, we observed that the serum Klotho level was significantly higher in CKD patients as compared to healthy volunteers, which is contrary to various studies like Akimoto et al., 2012; Asai et al., 2012; Hu et al., 2010; Xiao et al., 2004; and Yamazaki et al., 2010, where a decrease in serum Klotho was observed with progression in CKD. The gene discussed is KL; the disease is chronic kidney disease.