The disease progression of CKD affects other organ systems like cardiovascular, bone metabolism, erythropoietic hemostasis, etc. These conditions have led to intense research in both animals and humans to identify risk factors and early diagnostic markers of CKD [11]. Recent studies have implicated that Klotho, which was described as an anti-aging gene, has an association with the development and progression of CKD. The gene discussed is KL; the disease is chronic kidney disease.