HMGB2 and cancer: Among the infiltrated CD8+ T cells, ten genes were identified to be related to ccRCC prognosis and six were reported to be valuable in predicting cancer prognosis; including AMD1 for assessing patients with gastric cancer (22), CIB1, PTP4A2, and HMGB2 for breast cancer (23–26), HMGN1 for leiomyosarcoma (27), and RORA for glioma (28).