Among the infiltrated CD8+ T cells, ten genes were identified to be related to ccRCC prognosis and six were reported to be valuable in predicting cancer prognosis; including AMD1 for assessing patients with gastric cancer (22), CIB1, PTP4A2, and HMGB2 for breast cancer (23–26), HMGN1 for leiomyosarcoma (27), and RORA for glioma (28). The gene discussed is HMGN1; the disease is central nervous system cancer.