Because Alu retroelements, repetitive transposons, bind to Ro60 and activate TLR7 and TLR8 (73), the IC consisting of Ro60, Alu retroelements, and autoantibodies is formed in lupus-prone mice and internalized by autoreactive B cells or DCs via the BCR or FcR, respectively. The gene discussed is RO60; the disease is systemic lupus erythematosus.