AGBL3 and rheumatoid arthritis: Importantly, this was true for ‘all comers’ who were anti-CCP3 positive at baseline at standard cut-off levels, as well as in individuals stratified by at baseline by the presence of either high-positive anti-CCP3 levels or the SE, although the loss of significance of an associations of high positive anti-CCP3 levels in multivariate analyses suggest that the dual positivity for RFs and SE are stronger predictors of incident IA/RA.