In univariate analyses, compared to individuals who did not develop incident IA/RA, at their baseline visit the individuals who developed incident IA/RA had a higher prevalence of positivity for at least one allele containing the shared epitope, a higher prevalence of an anti-CCP3 level >2 and >3 times the upper limit of normal as well as a higher prevalence of positivity for both RF-IgA and RF-IgM (Table 1). Here, CD40LG is linked to rheumatoid arthritis.