RF patterns at last visit, or visit prior to incident IA/RA, n (%) RF-IgA(-) RF-IgM(-) RF-IgA(-) RF-IgM(+) RF-IgA(+) RF-IgM(-) RF-IgA(+) RF-IgM(+). The gene discussed is CD40LG; the disease is rheumatoid arthritis.