CD40LG and rheumatoid arthritis: Autoantibody patterns at or after developing incident IA/RA, n (%) Anti-CCP3 positive standard cut-off (>=20 units) Anti-CCP3 >2 x upper limit of normal (>40 units) Anti-CCP3 >3x upper limit of normal (>60 units) RF-IgA(-) RF-IgM(-) RF-IgA(-) RF-IgM(+) RF-IgA(+) RF-IgM(-) RF-IgA(+) RF-IgM(+)