In these analyses (Figure 3), in women, samples that were negative for anti-CCP3 and both RF isotypes were a median of 5.90 years from a diagnosis of RA compared to samples that were ‘triple’ positive for anti-CCP3, RF-IgA and RF-IgM that were a median of 1.08 years prior to a diagnosis of RA. The gene discussed is CD40LG; the disease is rheumatoid arthritis.