CD40LG and rheumatoid arthritis: In these analyses, in both SE positive and negative individuals the incidence of IA was significantly higher in individuals who were dual RF-IgA and RF-IgM positive (Figures 1B, C), although the lowest incidence of IA/RA was in individuals who were SE negative and did not have at baseline dual positivity for RF-IgA and RF-IgM (Figure 1C).