SOCS2 and Familial prostate cancer: Furthermore, SOCS2 (Figures 4F, G; Spearman coefficient: R = −0.61, p < 0.0001), RRM2 (Figures 4F, G; Spearman coefficient: R = −0.39, p < 0.0001), TPP1 (Figures 4F, G; Spearman coefficient: R = −0.21, p = 2.3e−06), and C11orf54 (Figures 4F, G; Spearman coefficient: R = −0.33, p = 4.7e−14) showed significant negative correlation between gene methylation and expression in prostate cancer, whereas the expression of EGFR (Figure 4F; p > 0.05) showed no significant correlation with gene methylation.