Interestingly, OPTN (Optineurin) seems partially reduced after LPS-stimulation, as well as the anti-inflammatory tyrosine kinase LYN, thus possibly inducing the stress of the endoplasmic reticulum and increasing autophagy during TRAPS-related inflammatory flares (Supplementary Table S8), as already described by our group (10, 44, 45). This evidence concerns the gene LYN and TNF receptor 1-associated periodic fever syndrome.