- Impaired Treg super enhancer activation- Impaired expression of Treg signature genes- Severe autoimmunity due to Treg cell deficiency- IgE hyperproduction- reduced efficiency of thymocyte differentiation into CD4SP thymocytes- inappropriate T cell lineage specification after MHC class I/II-mediated selection- failure to generate NKT and Treg cells. The gene discussed is IGHE; the disease is Autoimmunity.