PLK1 (36), MAPK (37), ATR (38), MCM (39), PI3K and FGFR1 (40) have been shown to play increasingly crucial regulatory roles in HCC, and these studies and our results indicated that CFHR4 may inhibit the development and progression of HCC by regulating these signaling pathways. The gene discussed is ATR; the disease is hepatocellular carcinoma.