In our study, all IgG aCL determinations by CIA in the first and second samples were below 95 UI (the equivalent of 40 GPL and MPL) and the two patients that met APS classification criteria had low levels of IgG aCL (30.8 CU and 26.9 CU in the first determination and 26.9 CU and 33.6 CU in the second), respectively. The gene discussed is ACLY; the disease is autoimmune polyendocrinopathy.