PRKN and Parkinson disease: Prkn-/- or Pink1-/- mice could mimic the phenotypes of Parkinson’s disease, which is accompanied by mitochondrial stress responses and the release of DAMPs, thus leading to the release of a large number of inflammatory factors through the STING-mediated IFN-I response, whereas knockout of STING reduced inflammation and improved the disease phenotype of Prkn-/- or Pink1-/- mice (41).