TSC1 and neoplasm: NDRG2, ALDH2, DIABLO, TARDBP, KLF9, HMGB1, CFLAR, FAS, SQSTM1, SIRT2, RNF31, SIRT3, BCL2, CYLD and TSC1 were downregulated in tumor tissues, while HSPA4, CASP8, PANX1, RIPK1, FADD, LEF1, SPATA2, EZH2, TNFSF10, DDX58, MYCN, TNF, PGAM5, CXCL1, PLK1, TNFRSF21, IDH2 and CDKN2A were upregulated (Supplementary Figure 1A).