NDRG2, ALDH2, DIABLO, TARDBP, KLF9, HMGB1, CFLAR, FAS, SQSTM1, SIRT2, RNF31, SIRT3, BCL2, CYLD and TSC1 were downregulated in tumor tissues, while HSPA4, CASP8, PANX1, RIPK1, FADD, LEF1, SPATA2, EZH2, TNFSF10, DDX58, MYCN, TNF, PGAM5, CXCL1, PLK1, TNFRSF21, IDH2 and CDKN2A were upregulated (Supplementary Figure 1A). The gene discussed is RNF31; the disease is neoplasm.