The results indicated that the mRNA expression levels of UBD, ATP1A3, ISG20 and CXCL11 are lower in SKOV3 and tumor samples than IOSE and normal tissues, which was consistent with the results of TCGA cohort, while HLA-DOB showed no difference, indicating the indispensable role of the key genes in the occurrence and development of OC (*: P<0.05, **: P<0.01, ***: P<0.001, ***: P<0.0001) (Figure 10B). This evidence concerns the gene UBD and neoplasm.