We investigated their level of activation compared to WT BM-DCs upon infection at MOI 50 with two pairs of virulent and avirulent L. interrogans: the virulent Verdun Cl3 and avirulent Cl3 p104 strains, as well as the L495 Manilae and avirulent M895 mutant, a defined mutant obtained by random mutagenesis harboring a LPS with truncated O antigen (19). Here, ADGRL3 is linked to infection.