Abnormal liver function: (ALT elevation greater than 1.5 times the upper limit of normal); renal dysfunction (creatinine and/or blood urea nitrogen or urea elevation greater than 1.5 times the upper limit of normal); hemolytic anemia, thrombocytopenia (PLT < 60 ×109/L), white blood cells <3 × 109/L, neutrophils <1.5 × 109/L; central or peripheral nervous system involvement. This evidence concerns the gene GPT and Abnormal renal physiology.