↓ frequency and duration of asthma exacerbations, use of reliever medications↑ time to the next asthma exacerbation↑ serum T lymphocyte, CD4+CD25+FOXP3+, CD8+, CD3−CD16+CD56+↓ serum CD69+ and CD25+ subset of CD3+. The gene discussed is FOXP3; the disease is asthma.