In contrast, other pathways prominently change their information flow at PBMC or normal as compared to tumor tissue: (i) turn off (BAG), (ii) decrease (such as BAFF, FLT3, and IL1), (iii) turn on (such as GAS and LIGHT), or (iv) increase (such as MIF, PARs, ANNEXIN, and IL16). This evidence concerns the gene TNFSF13B and neoplasm.