IL16 and neoplasm: In contrast, other pathways prominently change their information flow at PBMC or normal as compared to tumor tissue: (i) turn off (BAG), (ii) decrease (such as BAFF, FLT3, and IL1), (iii) turn on (such as GAS and LIGHT), or (iv) increase (such as MIF, PARs, ANNEXIN, and IL16).