In contrast, other pathways prominently change their information flow at PBMC or normal as compared to tumor tissue: (i) turn off (BAG), (ii) decrease (such as BAFF, FLT3, and IL1), (iii) turn on (such as GAS and LIGHT), or (iv) increase (such as MIF, PARs, ANNEXIN, and IL16). The gene discussed is FLT3; the disease is neoplasm.