Moreover, as a direct systematic performance of the functions of the chemokines and other immunomodulators, the activities of the cancer immunity cycle (Figure 3D), including the release of cancer cell antigens (Step 1), trafficking of immune cells to tumors (Step 4), and infiltration of immune cells into tumors (Step 5), were found to be upregulated in the IGFBP7 high group. This evidence concerns the gene IGFBP7 and cancer.