AKT1 and muscle atrophy: Target genes of non-muscle atrophy-related differentially expressed TFs were more likely to be related to carbon metabolism, fatty acid metabolism, TCA cycle, and HIF-1 signaling pathway than the other gene set, while the target genes of muscle atrophy-related differentially expressed TFs were more likely to be related to PI3K–Akt signaling pathway, JAK–STAT signaling pathway, and cytokine–cytokine receptor interaction than the other gene set (Figure 4A).