CCR2 and heart failure: In heart failure induced by aortic constriction in mice (pressure overload TAC model) it has been indicated that cardiac resident (CCR2−) macrophages and recruited monocyte-derived (CCR2+Ly6Chigh) macrophages may have distinct and at least partly antagonistic effects (Liao et al., 2018; Revelo et al., 2021) suggesting that different macrophage populations in the heart may also differentially affect proarrhythmic remodeling.