AREG knockout mice showed reduced Cx43 phosphorylation and a pronounced Cx43 lateralization leading to arrhythmias and increased mortality after pulmonary artery banding, while bone marrow transplantation (wildtype mice serving as donors) or treatment with recombinant AREG restored Cx43 phosphorylation/localization and prevented SCD (Sugita et al., 2021) (Figure 2B). This evidence concerns the gene AREG and Schnyder corneal dystrophy.