LYVE1+FOLR2+ macrophages are monocyte-derived and express the chemoattractant cytokine genes CCL13 and CCL18. Patients with dilated cardiomyopathy showed reduced numbers of LYVE1+ resident macrophages (subsets expressed FOLR2 and HSPH1) and an increased number of inflammatory macrophages (subsets expressed TREM2, CCL3 and KLF2) (Koenig et al., 2022). This evidence concerns the gene FOLR2 and dilated cardiomyopathy.