In different ischemia-reperfusion injury mouse models applied on hepatic and cardiac tissues, increased levels of p-PI3K, p-Akt have been recorded, indicating that I/R may activate the PI3K/Akt signaling pathway to initiate tissue repair following injury (Zhang et al., 2014; Thokala et al., 2017). This evidence concerns the gene AKT1 and ischemia reperfusion injury.