An Interactome protein, ADIPOQ or adiponectin (Robinson et al., 2011), similar to eNAMPT (aka visfatin), is a pro-inflammatory adipokine (Robinson et al., 2011; Dakroub et al., 2021; Mitsis et al., 2022) and known ARDS candidate gene/protein (Ahasic et al., 2014). This evidence concerns the gene ADIPOQ and acute respiratory distress syndrome.