TLR4 and acute respiratory distress syndrome: In summary, eNAMPT, a novel cytozyme and DAMP, is a highly druggable ARDS target with biochemical and genomic studies strongly supporting the mechanism of action for the eNAMPT-neutralizing humanized mAb ALT-100 mAb via attenuation of eNAMPT/TLR4 inflammatory cascade activation.