Injection of APS into the SMs of non-insulin-dependent type 2 diabetic KKAy mice ameliorated insulin resistance and hyperglycemia, and reduced MSTN levels in SM, which demonstrated APS might improve insulin sensitivity and reduce SM MSTN levels by downregulating the ROS-ERK-NF-κB pathway (Liu et al., 2013). The gene discussed is INS; the disease is Insulin resistance.