As a member of the highly conserved Src family of cytoplasmic protein tyrosine kinases, hematopoietic cell kinase (HCK) transmits a variety of extracellular signals and affects cell proliferation and migration Wei et al. (2017) suggested that HCK was a key mediator for renal fibrosis, with the reason that HCK overexpression activated the transforming growth factor-β/Smad3 pathway in vitro experiments, which promoted fibroblast proliferation and inflammatory expansion. This evidence concerns the gene SMAD3 and renal fibrosis.