PPARGC1A and coronary artery disorder: In total, 23 studies from the GENIUS-CHD consortium with established CHD and available SNP data in the PPARGC1A gene were selected, with the lead SNPs available in 22, 17, and 19 studies and highly correlated (r2 > 0.8 in Europeans) proxies available in 0, 2, and 2 studies for rs8192678 (non-synonymous variant G482S), rs7672915 (single nucleotide variant in intron 2), and rs3755863 (synonymous variant T528T), respectively (Figure 1).