PPARGC1A and coronary artery disorder: Although not found associated with CHD in genome-wide association studies (Peden et al., 2011; Schunkert et al., 2011; Deloukas et al., 2013; Nikpay et al., 2015; van der Harst and Verweij, 2018), PPARGC1A polymorphisms have been associated with the risk of the first-time CHD event and severity in candidate gene association studies (Zhang et al., 2008; Yongsakulchai et al., 2016; Maciejewska-Skrendo et al., 2019).