PPARGC1A and coronary artery disorder: However, there are studies that indicate that the PPARGC1A gene is important for the development of CAD (Zhang et al., 2008; Yongsakulchai et al., 2016; Maciejewska-Skrendo et al., 2019) and cardiometabolic disease phenotypes (Ek et al., 2001; Barroso et al., 2006; Xie et al., 2007; Lai et al., 2008b; Vimaleswaran et al., 2008; Yang et al., 2011; Franks et al., 2014; Jemaa et al., 2015; Kruzliak et al., 2015).