PPARGC1A and type 2 diabetes mellitus: Human studies have shown associations between a non-synonymous coding variant single nucleotide polymorphism (SNP) in PPARGC1A (G482S; rs8192678) and metabolic outcomes (Vandenbeek et al., 2017) such as adiposity, insulin resistance (Franks et al., 2014), type 2 diabetes (T2D) (Ek et al., 2001), and hypertension (Andersen et al., 2005).