Several processes important for atherosclerosis, such as lipid homeostasis (Zhang et al., 2004; Lin et al., 2005), endothelial function, and inflammation, are potentially modulated by the peroxisome proliferator–activated receptor gamma coactivator-1 alpha (PPARGC1A), encoded by the PPARGC1A gene (Kadlec et al., 2016). Here, PPARGC1A is linked to atherosclerosis.