The PPARGC1A gene (rs8192678; G482S) was further associated with T2D in a Tunisian population (Jemaa et al., 2015), with waist circumference among Slovenian participants with T2D (Kruzliak et al., 2015) and with severe hypertension in a Chinese population (Xie et al., 2007). This evidence concerns the gene PPARGC1A and type 2 diabetes mellitus.