Thus, although we suspect that mechanisms other than LDL reduction contribute to a protective effect of ACLY inhibition on CKD, as bempedoic acid has a much larger effect on ACLY inhibition than our ACLY eQTL genetic score, it is possible for bempedoic acid to have a larger effect on CKD prevention than the 9% reduction we observed with the ACLY eQTL genetic instrument. The gene discussed is ACLY; the disease is chronic kidney disease.