Concordant with the CKD observation, Mendelian randomization revealed significant association between reduced ACLY expression and reduced risk of the dichotomous “Rapid3” phenotype (OR = 0.88, 95% CI: 0.78–1.00, P = 0.05) with the weighted median model, whereas the inverse variance weighted model revealed similar effect size albeit above the significance threshold (OR = 0.88, 95% CI: 0.76–1.01, P = 0.07). The gene discussed is ACLY; the disease is chronic kidney disease.