COLCA1 and colorectal carcinoma: Compared with the previous largest TWAS study for CRC, which detected 25 associated genes with CRC risk at a Bonferroni-corrected threshold of P < 9.10 × 10−6 by MetaXcan software, we found that three of the significant TWAS genes (C11orf53, COLCA1, and COLCA2) were overlapped with the TWAS result performed by Guo et al. [36].