rs6507874 is the lead SNP of the genomic risk locus and is found in the intron of the SMAD7 gene (Figure S3c), while the previous research that studied the relationship between rs6507874 and CRC risk showed that rs6507874 did not show a statistically significant connection (P = 0.075) with increased SMAD7 expression [31]. This evidence concerns the gene SMAD7 and colorectal carcinoma.