In this study, we found that NAV3 expression was distinctly downregulated in CRC and predicted a favorable prognosis in CRC patients, which was not consistent with the findings of Uboveja et al. For the analysis of the correlation of NAV3 expression and the TME, we analyzed the relationship between NAV3 and a wide variety of TIC subtypes. Here, NAV3 is linked to colorectal carcinoma.