T helper cells type 2 (Th2), another subset of T lymphocytes, is essential in the process of asthma, secreting CKs such as IL-4, IL-5, and IL-13 that directly impair lung tissue or indirectly facilitate the proliferation of IgE-generating B cells and EOS, contributing to AHR and airway remodeling [29]. The gene discussed is IL4; the disease is asthma.