RYR2 and hepatocellular carcinoma: Second, we analyzed the mutation frequency of common genes in HCC based on different POLE expression in 271 cases, including TP53, TTN, CTNNB1, MUC16, ALB, PCLO, RYR2, MUC4, ABCA13, APOB and POLE, with mutation frequency of TP53 ranking the first (28%).