Zhang et al. reported that paclitaxel and cisplatin activated the caspase3/Gasdermin E (GSDME) pathway to induce pyroptosis in A549 cells, and Xu et al. indicated that downregulation of miR-155-5p can enhance apoptosis and pyroptosis to improve the anti-tumor effect of cetuximab10, 11. Here, GSDME is linked to neoplasm.