In the pediatric TBI population, trauma-related coagulopathy (platelet count < 150,000/μl, fibrinogen < 180 mg/dl, aPTT > 1.2, or prothrombin time > 1.3) in TBI pediatric patients was associated with worse neurological outcomes (Podolsky-Gondim et al., 2018). Here, F2 is linked to blood coagulation disease.