Because of the abundance of this NF-kB-upregulated miRNA-30b in the human brain and CNS neurons, with its significant over-expression in AD and this miRNA's known impact on human neurophysiological effects and pathways relevant to neurodegenerative disease, we further examined miRNA-30b as a potential regulator of NF-L gene expression. Here, NEFL is linked to neurodegenerative disease.