NEFL and nervous system disorder: A remarkably high number of neurological disorders exhibit NF-L degradation and the liberation of NF-L from neuron-specific compartments, mobilization, and enrichment into pathological biofluids in the periphery; this may be due to deficits in plasma membrane barrier's integrity and pathological transport and/or vesicle-mediated trafficking dysfunction of this highly stable 61,517 Da filament protein from diseased neurons [(19–28); https://www.genecards.org/cgi-bin/carddisp.pl?gene=NEFL; last accessed 24 April 2022].