NEFL and Alzheimer disease: We provide the first evidence that increased miRNA-30b is capable of targeting the 3'-UTR of the neuron-specific neurofilament light (NF-L) chain messenger RNA (mRNA), thus linking this action to the decreased expression of NF-L, a cytoskeletal element known to be downregulated within CNS neurons in AD affected brain, in stressed HNG cells in primary culture and in transgenic murine models of AD (14–21).