NFKB1 and Alzheimer disease: This NF-kB-sensitive miRNA-30b-mediated pathogenic interaction may be related to the downregulation of other immune, inflammatory, and synaptic system gene expression by pathological upregulation of miRNAs in the CNS, thereby resulting in altered cytoskeletal dynamics and neuronal atrophy as is observed in AD brain and in AD cellular and animal models associated with the progressive development of neocortical pathology (18, 33, 37–40, 42, 46–49, 51).