SNCA and Parkinson disease: These findings should be considered in light of the prolonged temporal course and the complex pathophysiology of these disorders, including a possible role for neuroinflammation: it is hypothesized that the body's innate response and subsequent inflammatory processes can induce a toxic cycle of accumulating β-amyloid and alpha-synuclein peptides (the pathologic hallmarks of Alzheimer's and Parkinson's diseases) (22–26).