Nonetheless, the Nlrp3D301NneoR/+; Gfi1Cre/+ mouse is the first mouse model to show overexpression of Nlrp3 in the cochlea and potentially associated hearing loss, which could also provide a valuable tool to investigate the link between mutant Nlrp3 overexpression and hearing loss, further revealing the underlying mechanism of immune-related pathophysiology of autoinflammatory hearing loss. Here, NLRP3 is linked to hearing loss disorder.