NLRP3 and CINCA syndrome: Accordingly, Nlrp3D301NneoR/+; Gfi1Cre/+ mice in our study grew poorly (Supplementary Figure 4) and did not survive longer than 3 weeks (mean survival: 17.5 ± 2.7 days, n = 24), which might have been partly due to the intrinsic effect of systemic Nlrp3 alterations corresponding to the phenotypes observed in human NLRP3-related autoinflammatory disorders, such as CINCA, which presents with fever, rash, joint symptoms, and central nervous system symptoms (19).