NLRP3 and cryopyrin-associated periodic syndrome: Alterations in the NLRP3 gene are associated with several autoinflammatory disorders affecting several organs, referred to as cryopyrin-associated periodic syndromes (CAPS), which include a spectrum of disorders—chronic infantile neurological cutaneous and articular syndrome (CINCA or NOMID, neonatal onset multisystem inflammatory disease), Muckle-Wells syndrome and familial cold autoinflammatory syndrome (FCAS) (5, 6).