A feeding study using soy protein and obese Zucker diabetic rats (an animal model for type II diabetes) showed lowered serum insulin and small increases in hepatic sterol regulatory element binding protein-1 (SREBP-1) mRNA; long-term soy protein feeding prevented hyperinsulinemia and decreased SREBP-1 mRNA, which led to lower hepatic triglycerides and cholesterol in obese Zucker diabetic rats (16). This evidence concerns the gene SREBF1 and hyperinsulinism.