Furthermore, the evidence show that dietary patterns characterized by high carbohydrate from refined grains are associated with obesity due to high glycemic index carbohydrates causes rapid changes in blood glucose and insulin levels, and sugar causes addictive cravings, glucose, and insulin signal the midbrain limbic system to change dopamine levels triggering inducement of food addiction (9). Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.